Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tgm5. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by structural data

• Tgm5 encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin E-set, Immunoglobulin-like fold, Protein-glutamine gamma-glutamyltransferase, eukaryota, Transglutaminase, C-terminal, Transglutaminase, conserved site, Transglutaminase, N-terminal, Transglutaminase-like, indicating that the gene product:
  • participates in the following biological processes:
    • peptide cross-linking
  • performs the following molecular functions:
    • protein-glutamine gamma-glutamyltransferase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tgm5 indicates that it:
  • performs the following molecular functions:
    • metal ion binding
    • transferase activity
    • transferase activity, transferring acyl groups
  • is located in the following cellular components:
    • cytoplasm
• Tgm5 has been associated with the Enzyme Commission numbers: 2.3.2.13, which implies that the gene product:
  • performs the following molecular functions:
    • protein-glutamine gamma-glutamyltransferase activity
• Annotations directly to for the gene Tgm5 indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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