Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables protein-glutamine gamma-glutamyltransferase activity. Involved in blood coagulation, fibrin clot formation. Acts upstream of or within blood coagulation and peptide cross-linking. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; hemolymphoid system; nervous system; reproductive system; and respiratory system. Used to study factor XIII deficiency. Human ortholog(s) of this gene implicated in artery disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Orthologous to human F13A1 (coagulation factor XIII A chain).