Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables signaling receptor activity. Acts upstream of or within negative regulation of blood vessel endothelial cell migration. Located in external side of plasma membrane. Is expressed in several structures, including forebrain; genitourinary system; neural retina; submandibular gland; and vascular system. Human ortholog(s) of this gene implicated in aortic valve disease 3. Orthologous to human ROBO4 (roundabout guidance receptor 4).