Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables DNA binding activity and ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination. Acts upstream of or within negative regulation of axon extension; positive regulation of transcription, DNA-templated; and ubiquitin-dependent protein catabolic process. Located in PML body; axon; and cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in esophageal cancer and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6).