Automated description from the Alliance of Genome Resources (Release 3.1.1)
Involved in several processes, including maintenance of animal organ identity; non-motile cilium assembly; and positive regulation of protein binding activity. Localizes to ciliary base and ciliary inversin compartment. Is expressed in embryo. Used to study autosomal dominant polycystic kidney disease and nephronophthisis 3. Human ortholog(s) of this gene implicated in Meckel syndrome 7; Senior-Loken syndrome; nephronophthisis; nephronophthisis 3; and renal-hepatic-pancreatic dysplasia. Orthologous to human NPHP3 (nephrocystin 3).