Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Irak3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Irak3
  • participates in the following biological processes:
    • cytokine-mediated signaling pathway ^[2]
    • interleukin-1-mediated signaling pathway ^[2]
    • positive regulation of NF-kappaB transcription factor activity ^[2]
    • protein autophosphorylation ^[2]
    • protein phosphorylation ^[2]
    • regulation of protein complex disassembly ^[2]
  • performs the following molecular functions:
    • ATP binding ^[2]
    • magnesium ion binding ^[2]
    • protein kinase activity ^[2]
    • protein serine/threonine kinase activity ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[3]
    • nucleus ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Irak3
  • participates in the following biological processes:
    • negative regulation of innate immune response ^[1]
    • negative regulation of interleukin-12 production ^[1]
    • negative regulation of interleukin-6 production ^[1]
    • negative regulation of macrophage cytokine production ^[1]
    • negative regulation of MAP kinase activity ^[3]
    • negative regulation of protein catabolic process ^[3]
    • negative regulation of toll-like receptor signaling pathway ^[1]
    • negative regulation of tumor necrosis factor production ^[1]
    • positive regulation of macrophage tolerance induction ^[1]
    • response to exogenous dsRNA ^[1]
    • response to lipopolysaccharide ^[1]
    • response to peptidoglycan ^[1]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Irak3
  • participates in the following biological processes:
    • negative regulation of cytokine-mediated signaling pathway ^[1]
    • response to virus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Irak3:
  • participates in the following biological processes:
    • interleukin-1-mediated signaling pathway
    • negative regulation of interleukin-12 production
    • negative regulation of interleukin-6 production
    • negative regulation of MAP kinase activity
    • negative regulation of NF-kappaB transcription factor activity
    • negative regulation of protein catabolic process
    • negative regulation of protein complex disassembly
    • negative regulation of tumor necrosis factor production
    • positive regulation of NF-kappaB transcription factor activity
    • protein phosphorylation
    • response to interleukin-1
  • performs the following molecular functions:
    • ATP binding
    • magnesium ion binding
    • protein heterodimerization activity
    • protein homodimerization activity
    • protein serine/threonine kinase activity
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Irak3 encodes a protein or proteins that contain the following InterPro domains: Death, DEATH-like, Protein kinase, catalytic domain, Protein kinase-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Irak3 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • kinase activity
    • nucleotide binding
    • transferase activity
• Predictions based on reviewed computational analyses of large-scale experimental data sets indicates that Irak3:
  • participates in the following biological processes:
    • apoptotic process
    • regulation of apoptotic process

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References

1. Kobayashi K et al. (2002) IRAK-M is a negative regulator of Toll-like receptor signaling. Cell, 110:191-202. (PubMed:12150927)
2. Rosati O et al. (2002) Identification and characterization of murine IRAK-M. Biochem Biophys Res Commun, 293:1472-7. (PubMed:12054681)
3. Su J et al. (2007) Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling. Cell Signal, 19:1596-601. (PubMed:17379480)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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