Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cby1. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 15, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cby1
  • is located in the following cellular components:
    • microtubule basal body ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cby1
  • participates in the following biological processes:
    • cardiac muscle cell differentiation ^[2]
    • cilium assembly ^[3]
    • fat cell differentiation ^[1]
    • negative regulation of canonical Wnt receptor signaling pathway ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cby1:
  • participates in the following biological processes:
    • negative regulation of transcription, DNA-dependent
    • negative regulation of Wnt receptor signaling pathway
    • protein localization
  • performs the following molecular functions:
    • beta-catenin binding
    • identical protein binding
  • is located in the following cellular components:
    • nucleus
    • trans-Golgi network

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cby1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
  • is located in the following cellular components:
    • Golgi apparatus

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References

1. Li FQ et al. (2007) Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. Mol Cell Biol, 27:4347-54. (PubMed:17403895)
2. Singh AM et al. (2007) Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells. Circulation, 115:617-26. (PubMed:17261658)
3. Voronina VA et al. (2009) Inactivation of Chibby affects function of motile airway cilia. J Cell Biol, 185:225-33. (PubMed:19364920)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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