Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc17a7. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc17a7
  • participates in the following biological processes:
    • L-glutamate import ^[]
  • is located in the following cellular components:
    • cerebellar mossy fiber ^[]
    • excitatory synapse ^{[, , ]}
    • presynaptic active zone ^[]
    • synapse ^{[, ]}
    • synaptic vesicle ^[]
    • synaptic vesicle membrane ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc17a7
  • participates in the following biological processes:
    • L-glutamate import ^[]
    • long-term memory ^[]
    • regulation of excitatory postsynaptic membrane potential ^[]
    • sequestering of neurotransmitter ^[]
    • synaptic transmission ^[]
    • synaptic transmission, glutamatergic ^[]
• Researchers have inferred, based on genetic interactions, that the gene product of Slc17a7
  • participates in the following biological processes:
    • L-glutamate import based on interactions with Slc30a3 ^[]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc17a7:
  • participates in the following biological processes:
    • phosphate ion transmembrane transport
    • phosphate ion transport
    • sodium ion transmembrane transport
    • sodium-dependent phosphate transport
  • performs the following molecular functions:
    • inorganic phosphate transmembrane transporter activity
    • sodium-dependent phosphate transmembrane transporter activity
    • sodium:inorganic phosphate symporter activity
  • is located in the following cellular components:
    • excitatory synapse
    • integral component of membrane
    • intracellular organelle
    • synapse

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Summary text based on GO annotations supported by structural data

• Slc17a7 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • participates in the following biological processes:
    • transmembrane transport

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc17a7 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • neurotransmitter transport
    • response to stimulus
    • sodium ion transport
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • cell junction
    • cytoplasmic vesicle
    • membrane
    • neuron projection

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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