Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of 2810006K23Rik. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

---

Summary text based on GO annotations supported by structural data

• 2810006K23Rik encodes a protein or proteins that contain the following InterPro domains: Peptide chain release factor class I/class II, indicating that the gene product:
  • participates in the following biological processes:
    • translational termination
  • performs the following molecular functions:
    • translation release factor activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe 2810006K23Rik indicates that it:
  • participates in the following biological processes:
    • translation
  • is located in the following cellular components:
    • mitochondrion
• Annotations directly to for the gene 2810006K23Rik indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---