Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Uaca. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Uaca
  • participates in the following biological processes:
    • positive regulation of apoptotic process ^[3]
    • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ^[3]
  • is located in the following cellular components:
    • apoptosome ^[3]
    • cytoplasm ^{[1, 2]}
    • cytosol ^[3]
    • membrane ^[2]
    • nuclear envelope ^{[1, 2]}
    • nucleus ^[3]
    • perinuclear region of cytoplasm ^[3]
• The gene product of Uaca has been shown to bind to the gene products of Lgals4. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Uaca
  • participates in the following biological processes:
    • intrinsic apoptotic signaling pathway in response to DNA damage ^[3]
    • intrinsic apoptotic signaling pathway in response to oxidative stress ^[3]
    • negative regulation of inflammatory response ^[1]
    • negative regulation of NF-kappaB import into nucleus ^[1]
    • positive regulation of apoptotic process ^[1]
    • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ^[3]
    • positive regulation of protein import into nucleus ^[3]
    • response to UV ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Uaca:
  • is located in the following cellular components:
    • cytoplasm
    • mitochondrion
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Uaca indicates that it:
  • is located in the following cellular components:
    • cytoskeleton

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References

1. Liu L et al. (2004) Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling. Biochem J, 380:31-41. (PubMed:14961764)
2. Sakai T et al. (2003) Identification of a novel, embryonal carcinoma cell-associated molecule, Nucling, that is pp-regulated during cardiac muscle differentiation. J Biochem, 133:429-36. (PubMed:12761289)
3. Sakai T et al. (2004) Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis. J Biol Chem, 279:41131-40. (PubMed:15271982)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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