Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables transcription regulator inhibitor activity. Involved in negative regulation of canonical NF-kappaB signal transduction and negative regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway; negative regulation of inflammatory response; and positive regulation of protein import into nucleus. Located in several cellular components, including cytosol; nuclear envelope; and perinuclear region of cytoplasm. Part of apoptosome. Is expressed in several structures, including cerebral cortex ventricular layer; genitourinary system; heart; liver; and lung. Used to study hepatocellular carcinoma. Orthologous to human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats).