Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Faim2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Faim2
  • is located in the following cellular components:
    • membrane raft ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Faim2
  • participates in the following biological processes:
    • cerebellar granular layer development ^[2]
    • cerebellar Purkinje cell differentiation ^[2]
    • cerebellar Purkinje cell layer development ^[2]
    • cerebellum development ^[2]
    • regulation of neuron apoptotic process ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Faim2:
  • participates in the following biological processes:
    • regulation of neuron apoptotic process
  • is located in the following cellular components:
    • membrane raft

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Faim2 indicates that it:
  • participates in the following biological processes:
    • apoptotic process
  • is located in the following cellular components:
    • cell junction
    • integral to membrane
    • membrane
    • plasma membrane
    • postsynaptic membrane
    • synapse
• Annotations directly to molecular function for the gene Faim2 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Fernandez M et al. (2007) Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment. J Neurochem, 103:190-203. (PubMed:17635665)
2. Hurtado de Mendoza T et al. (2011) Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells. Proc Natl Acad Sci U S A, 108:17189-94. (PubMed:21957071)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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