Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Amer1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 13, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Amer1
  • participates in the following biological processes:
    • adipose tissue development ^[1]
    • bone development ^[1]
    • kidney development ^[1]
    • mesenchymal cell differentiation involved in kidney development ^[1]

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Amer1 indicates that it:
  • participates in the following biological processes:
    • Wnt receptor signaling pathway
  • performs the following molecular functions:
    • lipid binding
  • is located in the following cellular components:
    • cytoplasm
    • membrane
    • nucleus
    • plasma membrane
• Annotations directly to for the gene Amer1 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Moisan A et al. (2011) The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification. Dev Cell, 20:583-96. (PubMed:21571217)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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