Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Chst14. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of August 28, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Chst14:
  • participates in the following biological processes:
    • dermatan sulfate biosynthetic process
    • dermatan sulfate proteoglycan metabolic process
  • performs the following molecular functions:
    • N-acetylgalactosamine 4-O-sulfotransferase activity
  • is located in the following cellular components:
    • extracellular vesicular exosome

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Summary text based on GO annotations supported by structural data

• Chst14 encodes a protein or proteins that contain the following InterPro domains: Carbohydrate sulfotransferase-related, Sulfotransferase, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate biosynthetic process
  • performs the following molecular functions:
    • sulfotransferase activity
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Chst14 indicates that it:
  • participates in the following biological processes:
    • carbohydrate metabolic process
  • performs the following molecular functions:
    • transferase activity
  • is located in the following cellular components:
    • Golgi apparatus
    • integral component of membrane
    • membrane

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References

1. Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res, 11:1758-65. (PubMed:11591653)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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