Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc39a4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The transmembrane protein is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica, a rare inherited defect in the absorption of dietary zinc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc39a4
  • participates in the following biological processes:
    • cellular response to zinc ion starvation ^[2]
    • cellular zinc ion homeostasis ^[3]
    • zinc ion transmembrane transport ^{[1, 3]}
    • zinc ion transport ^{[1, 3]}
  • performs the following molecular functions:
    • zinc ion transmembrane transporter activity ^{[1, 3]}
  • is located in the following cellular components:
    • apical plasma membrane ^{[1, 2]}
    • cytoplasmic membrane-bounded vesicle ^[3]
    • endosome ^[3]
    • plasma membrane ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc39a4:
  • is located in the following cellular components:
    • cytoplasmic membrane-bounded vesicle
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Slc39a4 encodes a protein or proteins that contain the following InterPro domains: Zinc/iron permease, indicating that the gene product:
  • participates in the following biological processes:
    • metal ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • metal ion transmembrane transporter activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc39a4 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Dufner-Beattie J et al. (2003) The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. J Biol Chem, 278:33474-81. (PubMed:12801924)
2. Dufner-Beattie J et al. (2004) The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5. J Biol Chem, 279:49082-90. (PubMed:15358787)
3. Kim BE et al. (2004) Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem, 279:4523-30. (PubMed:14612438)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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