Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ifih1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ifih1
  • participates in the following biological processes:
    • innate immune response ^[1]
    • response to virus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ifih1:
  • participates in the following biological processes:
    • positive regulation of interferon-alpha production
    • positive regulation of interferon-beta production
    • protein sumoylation
  • performs the following molecular functions:
    • double-stranded RNA binding
    • ribonucleoprotein complex binding
    • single-stranded RNA binding
    • zinc ion binding
  • is located in the following cellular components:
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Ifih1 encodes a protein or proteins that contain the following InterPro domains: C-terminal domain of RIG-I, Caspase Recruitment, Death-like domain, Helicase, C-terminal, Helicase, superfamily 1/2, ATP-binding domain, Helicase/UvrB domain, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of apoptotic process
  • performs the following molecular functions:
    • ATP binding
    • DNA binding
    • helicase activity
    • hydrolase activity
    • hydrolase activity, acting on acid anhydrides
    • nucleic acid binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ifih1 indicates that it:
  • participates in the following biological processes:
    • defense response to virus
  • performs the following molecular functions:
    • ATP binding
    • helicase activity
    • hydrolase activity
    • metal ion binding
    • nucleotide binding
    • RNA binding
  • is located in the following cellular components:
    • nucleus

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References

1. Loo YM et al. (2008) Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol, 82:335-45. (PubMed:17942531)
2. Miyashita M et al. (2011) DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling. Mol Cell Biol, 31:3802-19. (PubMed:21791617)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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