Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pex1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 9, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pex1
  • is located in the following cellular components:
    • peroxisome ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pex1:
  • participates in the following biological processes:
    • microtubule-based peroxisome localization
    • peroxisome organization
    • protein import into peroxisome matrix
    • protein targeting to peroxisome
  • performs the following molecular functions:
    • ATP binding
    • ATPase activity, coupled
    • protein C-terminus binding
    • protein complex binding
  • is located in the following cellular components:
    • cytoplasm
    • cytosol
    • intracellular membrane-bounded organelle
    • nucleus
    • peroxisomal membrane
    • peroxisome

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Summary text based on GO annotations supported by structural data

• Pex1 encodes a protein or proteins that contain the following InterPro domains: AAA+ ATPase domain, Aspartate decarboxylase-like fold, ATPase, AAA-type, conserved site, ATPase, AAA-type, core, Peroxisome biogenesis factor 1, Peroxisome biogenesis factor 1, alpha/beta, Peroxisome biogenesis factor 1, N-terminal, indicating that the gene product:
  • performs the following molecular functions:
    • nucleoside-triphosphatase activity
    • nucleotide binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pex1 indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport
  • performs the following molecular functions:
    • lipid binding
    • nucleotide binding
  • is located in the following cellular components:
    • membrane

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References

1. Kikuchi M et al. (2004) Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. J Biol Chem, 279:421-8. (PubMed:14561759)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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