Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Oxsm. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Oxsm
  • is located in the following cellular components:
    • mitochondrion ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Oxsm:
  • participates in the following biological processes:
    • acyl-CoA metabolic process
    • medium-chain fatty acid biosynthetic process
    • short-chain fatty acid biosynthetic process
  • performs the following molecular functions:
    • 3-oxoacyl-[acyl-carrier-protein] synthase activity
  • is located in the following cellular components:
    • cytoplasm
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Oxsm encodes a protein or proteins that contain the following InterPro domains: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Beta-ketoacyl synthase, active site, Beta-ketoacyl synthase, C-terminal, Beta-ketoacyl synthase, N-terminal, Thiolase-like, Thiolase-like, subgroup, indicating that the gene product:
  • participates in the following biological processes:
    • fatty acid biosynthetic process
    • metabolic process
  • performs the following molecular functions:
    • catalytic activity
    • transferase activity, transferring acyl groups other than amino-acyl groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Oxsm indicates that it:
  • participates in the following biological processes:
    • fatty acid biosynthetic process
    • fatty acid metabolic process
    • lipid metabolic process
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring acyl groups

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References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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