Automated description from the Alliance of Genome Resources (Release 3.2)
Predicted to have ubiquitin-ubiquitin ligase activity. Involved in negative regulation of interleukin-17 production and regulation of protein stability. Predicted to localize to several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. Is expressed in cranial ganglion; nervous system; sensory organ; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5).