Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mutyh. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mutyh
  • is located in the following cellular components:
    • mitochondrion ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mutyh:
  • participates in the following biological processes:
    • response to oxidative stress
  • performs the following molecular functions:
    • DNA N-glycosylase activity
    • MutSalpha complex binding
  • is located in the following cellular components:
    • mitochondrion
    • nucleus

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Summary text based on GO annotations supported by structural data

• Mutyh encodes a protein or proteins that contain the following InterPro domains: A/G-specific adenine glycosylase MutY, bacterial form, DNA glycosylase, Endonuclease III, conserved site-2, Endonuclease III, iron-sulphur binding site, Endonuclease III-like, iron-sulphur cluster loop motif, Helix-turn-helix, base-excision DNA repair, C-terminal, HhH-GPD domain, NUDIX hydrolase domain, NUDIX hydrolase domain-like, indicating that the gene product:
  • participates in the following biological processes:
    • base-excision repair
  • performs the following molecular functions:
    • 4 iron, 4 sulfur cluster binding
    • catalytic activity
    • endonuclease activity
    • hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mutyh indicates that it:
  • participates in the following biological processes:
    • metabolic process
    • response to DNA damage stimulus
  • performs the following molecular functions:
    • 4 iron, 4 sulfur cluster binding
    • hydrolase activity
    • hydrolase activity, acting on glycosyl bonds
    • iron-sulfur cluster binding
    • metal ion binding

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References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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