Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Arhgap17. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Arhgap17:
  • participates in the following biological processes:
    • actin filament organization
    • calcium ion-dependent exocytosis
  • is located in the following cellular components:
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Arhgap17 encodes a protein or proteins that contain the following InterPro domains: BAR domain, Rho GTPase activation protein, Rho GTPase-activating protein domain, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Arhgap17 indicates that it:
  • performs the following molecular functions:
    • GTPase activator activity
    • SH3 domain binding
  • is located in the following cellular components:
    • cell junction
    • membrane
    • tight junction
• Annotations directly to for the gene Arhgap17 indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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