Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Inf2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Inf2:
  • is located in the following cellular components:
    • cytoplasm
    • endoplasmic reticulum
    • nucleus
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Inf2 encodes a protein or proteins that contain the following InterPro domains: Actin-binding FH2, Actin-binding FH2/DRF autoregulatory, Armadillo-type fold, Diaphanous FH3, Diaphanous GTPase-binding, GTPase-binding/formin homology 3, WH2 domain, indicating that the gene product:
  • participates in the following biological processes:
    • actin cytoskeleton organization
    • cellular component organization
  • performs the following molecular functions:
    • actin binding
    • Rho GTPase binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Inf2 indicates that it:
  • performs the following molecular functions:
    • actin binding

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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