Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; histone H2AK15 ubiquitin ligase activity; and ubiquitin binding activity. Involved in isotype switching. Acts upstream of or within cellular response to UV and regulation of protein localization. Part of DNA repair complex. Is expressed in central nervous system and genitourinary system. Used to study RIDDLE syndrome. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168).