Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Yars2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Yars2
  • is located in the following cellular components:
    • mitochondrion ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Yars2:
  • participates in the following biological processes:
    • mitochondrial tyrosyl-tRNA aminoacylation
    • tRNA aminoacylation
  • performs the following molecular functions:
    • protein homodimerization activity
    • tRNA binding
    • tyrosine binding
    • tyrosine-tRNA ligase activity

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Summary text based on GO annotations supported by structural data

• Yars2 encodes a protein or proteins that contain the following InterPro domains: Aminoacyl-tRNA synthetase, class I, conserved site, Aminoacyl-tRNA synthetase, class Ic, RNA-binding S4 domain, Rossmann-like alpha/beta/alpha sandwich fold, Tyrosine-tRNA ligase, Tyrosine-tRNA ligase, bacterial-type, indicating that the gene product:
  • participates in the following biological processes:
    • tRNA aminoacylation for protein translation
    • tyrosyl-tRNA aminoacylation
  • performs the following molecular functions:
    • aminoacyl-tRNA ligase activity
    • ATP binding
    • nucleotide binding
    • RNA binding
  • is located in the following cellular components:
    • cytoplasm

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Yars2 indicates that it:
  • participates in the following biological processes:
    • translation
  • performs the following molecular functions:
    • aminoacyl-tRNA ligase activity
    • ATP binding
    • ligase activity
    • nucleotide binding

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References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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