Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in insulin receptor signaling pathway. Acts upstream of or within determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and heart development. Located in 9+2 motile cilium; centrosome; and cytoplasm. Is expressed in embryo; spermatozoon; and testis. Used to study Kartagener syndrome; primary ciliary dyskinesia 1; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 1. Orthologous to human DNAI1 (dynein axonemal intermediate chain 1).