Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ak8. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 17, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ak8
  • participates in the following biological processes:
    • ventricular system development ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ak8:
  • performs the following molecular functions:
    • adenylate kinase activity
    • cytidylate kinase activity

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Summary text based on GO annotations supported by structural data

• Ak8 encodes a protein or proteins that contain the following InterPro domains: Adenylate kinase, Adenylate kinase, active site lid domain, indicating that the gene product:
  • participates in the following biological processes:
    • nucleobase-containing compound metabolic process
  • performs the following molecular functions:
    • ATP binding
    • nucleobase-containing compound kinase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ak8 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity
  • is located in the following cellular components:
    • cytoplasm
• Annotations directly to for the gene Ak8 indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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References

1. Vogel P et al. (2012) Congenital hydrocephalus in genetically engineered mice. Vet Pathol, 49:166-81. (PubMed:21746835)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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