Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Srpx2. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on physical interactions, that the gene product of Srpx2
  • performs the following molecular functions:
    • receptor binding ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Srpx2
  • participates in the following biological processes:
    • positive regulation of cell migration involved in sprouting angiogenesis ^[1]
    • vocalization behavior ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Srpx2:
  • participates in the following biological processes:
    • cell motility
    • positive regulation of synapse assembly
    • regulation of phosphorylation
    • single organismal cell-cell adhesion
  • performs the following molecular functions:
    • hepatocyte growth factor binding
    • identical protein binding
    • receptor binding
  • is located in the following cellular components:
    • cell surface
    • cytoplasm
    • excitatory synapse
    • extracellular space
    • synaptic membrane

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Summary text based on GO annotations supported by structural data

• Srpx2 encodes a protein or proteins that contain the following InterPro domains: Domain of unknown function DUF4174, Hyalin, Sushi/SCR/CCP, indicating that the gene product:
  • participates in the following biological processes:
    • angiogenesis

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Srpx2 indicates that it:
  • participates in the following biological processes:
    • angiogenesis
    • cell adhesion
  • is located in the following cellular components:
    • cell junction
    • extracellular region
    • synapse

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References

1. Miljkovic-Licina M et al. (2009) Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB J, 23:4105-16. (PubMed:19667118)
2. Sia GM et al. (2013) The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice. Science, 342:987-91. (PubMed:24179158)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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