Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables AP-2 adaptor complex binding activity; clathrin heavy chain binding activity; and insulin receptor binding activity. Involved in clathrin-dependent endocytosis and gastrulation. Acts upstream of or within insulin receptor internalization; negative regulation of glucose import; and negative regulation of signal transduction. Located in clathrin-coated endocytic vesicle; lysosome; and plasma membrane. Is expressed in embryo; extraembryonic component; neural fold; and primitive streak. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblF. Orthologous to human LMBRD1 (LMBR1 domain containing 1).