Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ndufs3. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 7, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ndufs3
  • is located in the following cellular components:
    • mitochondrial inner membrane ^[1]
    • mitochondrion ^{[2, 3, 4]}

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ndufs3:
  • participates in the following biological processes:
    • induction of apoptosis
    • negative regulation of cell growth
    • oxidation-reduction process
    • reactive oxygen species metabolic process
  • performs the following molecular functions:
    • NADH dehydrogenase activity
  • is located in the following cellular components:
    • mitochondrial membrane
    • mitochondrial respiratory chain complex I

---

Summary text based on GO annotations supported by structural data

• Ndufs3 encodes a protein or proteins that contain the following InterPro domains: NADH dehydrogenase, subunit C, NADH:ubiquinone oxidoreductase, 30kDa subunit, NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site, indicating that the gene product:
  • performs the following molecular functions:
    • NADH dehydrogenase (ubiquinone) activity
    • oxidoreductase activity, acting on NAD(P)H

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ndufs3 indicates that it:
  • participates in the following biological processes:
    • electron transport chain
    • transport
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane
    • respiratory chain
• Ndufs3 has been associated with the Enzyme Commission numbers: 1.6.5.3, 1.6.99.3, which implies that the gene product:
  • performs the following molecular functions:
    • NADH dehydrogenase (ubiquinone) activity

---

References

1. Da Cruz S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem, 278:41566-71. (PubMed:12865426)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
4. Yang H et al. (2010) Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum Mol Genet, 19:170-80. (PubMed:19837698)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---