Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc25a22. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc25a22
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2]}

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc25a22:
  • participates in the following biological processes:
    • L-glutamate transport
  • performs the following molecular functions:
    • L-glutamate transmembrane transporter activity
  • is located in the following cellular components:
    • mitochondrial inner membrane
    • mitochondrion
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Slc25a22 encodes a protein or proteins that contain the following InterPro domains: Mitochondrial carrier domain, Mitochondrial carrier protein, Mitochondrial substrate/solute carrier, indicating that the gene product:
  • participates in the following biological processes:
    • transmembrane transport

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc25a22 indicates that it:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---