Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rpl38. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 12, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rpl38
  • participates in the following biological processes:
    • 90S preribosome assembly ^[1]
  • is located in the following cellular components:
    • eukaryotic 80S initiation complex ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rpl38
  • participates in the following biological processes:
    • axial mesoderm development ^[1]
    • middle ear morphogenesis ^[2]
    • ossification ^[2]
    • regulation of translation ^[1]
    • sensory perception of sound ^[2]
    • skeletal system development ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rpl38:
  • is located in the following cellular components:
    • cytosolic large ribosomal subunit

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Summary text based on GO annotations supported by structural data

• Rpl38 encodes a protein or proteins that contain the following InterPro domains: Ribosomal protein L38e, indicating that the gene product:
  • participates in the following biological processes:
    • translation
  • performs the following molecular functions:
    • structural constituent of ribosome
  • is located in the following cellular components:
    • intracellular
    • ribosome

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rpl38 indicates that it:
  • is located in the following cellular components:
    • ribonucleoprotein complex
    • ribosome
• Annotations directly to for the gene Rpl38 indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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References

1. Kondrashov N et al. (2011) Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Cell, 145:383-97. (PubMed:21529712)
2. Noben-Trauth K et al. (2011) Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse. J Biol Chem, 286:3079-93. (PubMed:21062742)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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