Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dock6. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]

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Summary text based on GO annotations supported by structural data

• Dock6 encodes a protein or proteins that contain the following InterPro domains: Dedicator of cytokinesis, Dedicator of cytokinesis C, Dedicator of cytokinesis C-terminal, Dedicator of cytokinesis C/D, N-terminal, DHR-1 domain, DHR-2 domain, indicating that the gene product:
  • participates in the following biological processes:
    • small GTPase mediated signal transduction
  • performs the following molecular functions:
    • guanyl-nucleotide exchange factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dock6 indicates that it:
  • performs the following molecular functions:
    • guanyl-nucleotide exchange factor activity
  • is located in the following cellular components:
    • cytoplasm
• Annotations directly to for the gene Dock6 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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