Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Alg2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 6, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Alg2:
  • participates in the following biological processes:
    • dolichol-linked oligosaccharide biosynthetic process
    • protein glycosylation in endoplasmic reticulum
    • response to calcium ion
  • performs the following molecular functions:
    • alpha-1,3-mannosyltransferase activity
    • calcium-dependent protein binding
    • protein anchor
    • protein heterodimerization activity
    • protein N-terminus binding
  • is located in the following cellular components:
    • cytoplasm
    • membrane
    • nucleus
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Alg2 encodes a protein or proteins that contain the following InterPro domains: Glycosyl transferase, family 1, indicating that the gene product:
  • participates in the following biological processes:
    • biosynthetic process

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Alg2 indicates that it:
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring glycosyl groups
  • is located in the following cellular components:
    • integral to membrane
• Alg2 has been associated with the Enzyme Commission numbers: 2.4.1.132, 2.4.1.257, which implies that the gene product:
  • performs the following molecular functions:
    • GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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