Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Erp29. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Erp29
  • is located in the following cellular components:
    • cell surface ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Erp29:
  • is located in the following cellular components:
    • cell surface
    • endoplasmic reticulum
    • transport vesicle

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Summary text based on GO annotations supported by structural data

• Erp29 encodes a protein or proteins that contain the following InterPro domains: Endoplasmic reticulum, protein ERp29, Endoplasmic reticulum, protein ERp29, C-terminal, ERp29, N-terminal, Thioredoxin-like fold, indicating that the gene product:
  • participates in the following biological processes:
    • protein secretion
  • is located in the following cellular components:
    • endoplasmic reticulum lumen

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References

1. Holbrook LM et al. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br J Haematol, 148:627-37. (PubMed:19995400)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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