Automated description from the Alliance of Genome Resources (Release 5.2.1)
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in in utero embryonic development and ribosome biogenesis. Acts upstream of or within several processes, including negative regulation of granulocyte differentiation; positive regulation of G1/S transition of mitotic cell cycle; and regulation of response to DNA damage stimulus. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and musculoskeletal system. Orthologous to human CUL4A (cullin 4A).