Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mastl. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mastl:
  • participates in the following biological processes:
    • G2/M transition of mitotic cell cycle
    • mitosis
    • negative regulation of protein phosphatase type 2A activity
    • protein phosphorylation
    • regulation of cell cycle
  • performs the following molecular functions:
    • kinase activity
    • protein serine/threonine kinase activity
  • is located in the following cellular components:
    • centrosome
    • cleavage furrow
    • nucleus

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Summary text based on GO annotations supported by structural data

• Mastl encodes a protein or proteins that contain the following InterPro domains: AGC-kinase, C-terminal, Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine-protein kinase, active site, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mastl indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • cell division
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding
    • transferase activity
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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