Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Oxct1. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 29, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Oxct1
  • participates in the following biological processes:
    • cellular ketone body metabolic process ^[4]
  • performs the following molecular functions:
    • 3-oxoacid CoA-transferase activity ^[4]
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Oxct1
  • participates in the following biological processes:
    • ketone body catabolic process ^[1]
    • ketone catabolic process ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Oxct1:
  • participates in the following biological processes:
    • cellular ketone body metabolic process
    • cellular response to acid
    • cellular response to glucose stimulus
    • positive regulation of insulin secretion
  • performs the following molecular functions:
    • 3-oxoacid CoA-transferase activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Oxct1 encodes a protein or proteins that contain the following InterPro domains: 3-oxoacid CoA-transferase, 3-oxoacid CoA-transferase, subunit A, 3-oxoacid CoA-transferase, subunit B, Coenzyme A transferase active site, Coenzyme A transferase binding site, Coenzyme A transferase family I, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • CoA-transferase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Oxct1 indicates that it:
  • performs the following molecular functions:
    • transferase activity

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References

1. Cotter DG et al. (2011) Obligate role for ketone body oxidation in neonatal metabolic homeostasis. J Biol Chem, 286:6902-10. (PubMed:21209089)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
4. Tanaka H et al. (2003) Differential expression of succinyl CoA transferase (SCOT) genes in somatic and germline cells of the mouse testis. Int J Androl, 26:52-6. (PubMed:12534938)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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