Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fancl. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fancl
  • participates in the following biological processes:
    • protein ubiquitination ^[3]
  • performs the following molecular functions:
    • ubiquitin-protein ligase activity ^[3]
• The gene product of Fancl has been shown to bind to the gene products of Ggn, Ube2w. ^{[2, 3]} Researchers have inferred, based on physical interactions, that the gene product of Fancl
  • performs the following molecular functions:
  • is located in the following cellular components:
    • nuclear envelope ^[2]
    • nucleus ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fancl
  • participates in the following biological processes:
    • gamete generation ^[1]
    • regulation of cell proliferation ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fancl:
  • participates in the following biological processes:
    • DNA repair
    • protein monoubiquitination
    • response to DNA damage stimulus
  • performs the following molecular functions:
    • ubiquitin protein ligase binding
    • ubiquitin-protein ligase activity
  • is located in the following cellular components:
    • Fanconi anaemia nuclear complex

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Summary text based on GO annotations supported by structural data

• Fancl encodes a protein or proteins that contain the following InterPro domains: Fanconi anemia complex, subunit FancL, WD-repeat containing domain, Zinc finger, RING-type, Zinc finger, RING/FYVE/PHD-type, indicating that the gene product:
  • performs the following molecular functions:
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fancl indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • ligase activity
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm

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References

1. Agoulnik AI et al. (2002) A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Hum Mol Genet, 11:3047-53. (PubMed:12417526)
2. Lu B et al. (2003) Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. J Biol Chem, 278:16289-96. (PubMed:12574169)
3. Zhang Y et al. (2011) UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. Mol Cells, 31:113-22. (PubMed:21229326)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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