Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits ubiquitin protein ligase activity. Involved in innate immune response; negative regulation of I-kappaB kinase/NF-kappaB signaling; and negative regulation of viral entry into host cell. Localizes to endoplasmic reticulum. Is expressed in several structures, including central nervous system; epidermis; forelimb bud; genitourinary system; and lung epithelium. Orthologous to human TRIM59 (tripartite motif containing 59).