Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acad8. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 30, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acad8
  • is located in the following cellular components:
    • mitochondrion ^[1]

---

Summary text based on GO annotations supported by structural data

• Acad8 encodes a protein or proteins that contain the following InterPro domains: Acyl-CoA dehydrogenase, conserved site, Acyl-CoA dehydrogenase, N-terminal, Acyl-CoA dehydrogenase/oxidase, Acyl-CoA dehydrogenase/oxidase C-terminal, Acyl-CoA dehydrogenase/oxidase, N-terminal, Acyl-CoA oxidase/dehydrogenase, central domain, Acyl-CoA oxidase/dehydrogenase, type 1, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • acyl-CoA dehydrogenase activity
    • flavin adenine dinucleotide binding
    • oxidoreductase activity, acting on the CH-CH group of donors

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acad8 indicates that it:
  • participates in the following biological processes:
    • branched-chain amino acid catabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity

---

References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---