Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cntnap2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cntnap2
  • is located in the following cellular components:
    • juxtaparanode region of axon ^{[3, 5, 6]}
    • voltage-gated potassium channel complex ^[6]
• The gene product of Cntnap2 has been shown to bind to the gene products of Cntn2. ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cntnap2
  • participates in the following biological processes:
    • cellular protein localization ^[3]
    • clustering of voltage-gated potassium channels ^[3]
    • protein localization to juxtaparanode region of axon ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Cntnap2
  • participates in the following biological processes:
    • neuron projection development based on interactions with Cntn2 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cntnap2:
  • participates in the following biological processes:
    • behavior
    • vocalization behavior
  • performs the following molecular functions:
    • enzyme binding
  • is located in the following cellular components:
    • axolemma
    • cell surface
    • early endosome
    • Golgi apparatus
    • membrane
    • voltage-gated potassium channel complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cntnap2 indicates that it:
  • is located in the following cellular components:
    • integral to membrane

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References

1. Horresh I et al. (2008) Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J Neurosci, 28:14213-22. (PubMed:19109503)
2. Lieberoth A et al. (2009) Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth. J Neurosci, 29:6677-90. (PubMed:19458237)
3. Poliak S et al. (2003) Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol, 162:1149-60. (PubMed:12963709)
4. Savvaki M et al. (2010) The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS. J Neurosci, 30:13943-54. (PubMed:20962216)
5. Savvaki M et al. (2008) Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. Mol Cell Neurosci, 39:478-90. (PubMed:18760366)
6. Traka M et al. (2003) Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J Cell Biol, 162:1161-72. (PubMed:12975355)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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