Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Foxp1. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 6, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Foxp1
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter ^{[5, 8, 9, 12]}
    • negative regulation of transcription, DNA-templated ^[9]
  • performs the following molecular functions:
    • chromatin binding ^[2]
    • DNA binding ^[5]
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ^[1]
    • sequence-specific DNA binding transcription factor activity ^{[6, 8]}
  • is located in the following cellular components:
    • nucleus ^{[1, 3, 6]}
• The gene product of Foxp1 has been shown to bind to the gene products of Ctbp1. ^[5] Researchers have inferred, based on physical interactions, that the gene product of Foxp1
  • performs the following molecular functions:
    • protein heterodimerization activity ^[5]
    • protein homodimerization activity ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Foxp1
  • participates in the following biological processes:
    • cardiac muscle cell differentiation ^[10]
    • cardiovascular system development ^[11]
    • embryo development ^[1]
    • heart development ^{[10, 11]}
    • immunoglobulin V(D)J recombination ^[1]
    • in utero embryonic development ^[11]
    • motor neuron axon guidance ^[7]
    • positive regulation of cardiac muscle cell differentiation ^[12]
    • positive regulation of immunoglobulin production ^[1]
    • positive regulation of transcription from RNA polymerase II promoter ^[12]
    • positive regulation of transcription, DNA-templated ^[7]
    • pre-B cell differentiation ^[1]
    • regulation of cardiac muscle cell proliferation ^[12]
  • performs the following molecular functions:
    • RNA polymerase II core promoter proximal region sequence-specific DNA binding ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Foxp1
  • participates in the following biological processes:
    • cardiovascular system development based on interactions with Nkx2-5 ^[11]
    • embryo development based on interactions with Foxp2 ^[8]
    • lung development based on interactions with Foxp2 ^[8]
    • lung secretory cell differentiation based on interactions with Foxp4 ^[4]
    • negative regulation of lung goblet cell differentiation based on interactions with Foxp4 ^[4]
    • negative regulation of transcription from RNA polymerase II promoter based on interactions with Ncor2 ^[2]
    • positive regulation of epithelial cell proliferation based on interactions with Foxp2 ^[8]
    • positive regulation of mesenchymal cell proliferation based on interactions with Foxp2 ^[8]
    • regulation of cardiac muscle cell proliferation based on interactions with Fgf20 ^[12]
    • regulation of lung goblet cell differentiation based on interactions with Agr2, Foxp4 ^[4]
    • sarcomere organization based on interactions with Nkx2-5 ^[11]
    • skeletal muscle tissue development based on interactions with Foxp2 ^[8]
    • smooth muscle tissue development based on interactions with Foxp2 ^[8]
    • transcription from RNA polymerase II promoter based on interactions with Ncor2 ^[2]
  • performs the following molecular functions:
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity based on interactions with Ncor2 ^[2]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Foxp1
  • is located in the following cellular components:
    • nucleus ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Foxp1:
  • participates in the following biological processes:
    • pattern specification process
  • performs the following molecular functions:
    • DNA binding, bending
  • is located in the following cellular components:
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Foxp1 encodes a protein or proteins that contain the following InterPro domains: Transcription factor, fork head, Transcription factor, fork head, conserved site, Winged helix-turn-helix DNA-binding domain, Zinc finger, C2H2-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-templated
  • performs the following molecular functions:
    • sequence-specific DNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Foxp1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-templated
    • transcription, DNA-templated
  • performs the following molecular functions:
    • metal ion binding

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References

1. Hu H et al. (2006) Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol, 7:819-26. (PubMed:16819554)
2. Jepsen K et al. (2008) Cooperative regulation in development by SMRT and FOXP1. Genes Dev, 22:740-5. (PubMed:18347093)
3. Kelly CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol, 11:e1001538. (PubMed:23610558)
4. Li S et al. (2012) Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development, 139:2500-9. (PubMed:22675208)
5. Li S et al. (2004) Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol, 24:809-22. (PubMed:14701752)
6. Morikawa Y et al. (2009) Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis. Dev Neurosci, 31:511-22. (PubMed:19797899)
7. Palmesino E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol, 8:e1000446. (PubMed:20711475)
8. Shu W et al. (2007) Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development, 134:1991-2000. (PubMed:17428829)
9. Shu W et al. (2001) Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem, 276:27488-97. (PubMed:11358962)
10. Wang B et al. (2004) Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development, 131:4477-87. (PubMed:15342473)
11. Wang Y et al. (2010) Pref-1 interacts with fibronectin to inhibit adipocyte differentiation. Mol Cell Biol, 30:3480-92. (PubMed:20457810)
12. Zhang Y et al. (2010) Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev, 24:1746-57. (PubMed:20713518)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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