Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin protein ligase activity. Involved in protein autoubiquitination. Acts upstream of or within dorsal/ventral neural tube patterning; noradrenergic neuron development; and protein monoubiquitination. Located in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220).