Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits mediator complex binding activity and promoter-specific chromatin binding activity. Involved in several processes, including cohesin loading; embryonic viscerocranium morphogenesis; and positive regulation of neuron migration. Localizes to chromatin and integrator complex. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and nose. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Orthologous to human NIPBL (NIPBL cohesin loading factor).