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Gene Ontology Classifications
Symbol
Name
ID
Lrrk2
leucine-rich repeat kinase 2
MGI:1913975

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lrrk2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 21, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Beilina A et al. (2014) Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci U S A, 111:2626-31. (PubMed:24510904)
  2. Biskup S et al. (2006) Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann Neurol, 60:557-69. (PubMed:17120249)
  3. Civiero L et al. (2012) Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. PLoS One, 7:e43472. (PubMed:22952686)
  4. Dorval V et al. (2014) Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS One, 9:e85510. (PubMed:24427314)
  5. Dusonchet J et al. (2014) A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Hum Mol Genet, 23:4887-905. (PubMed:24794857)
  6. Haebig K et al. (2010) ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One, 5:e13762. (PubMed:21048939)
  7. Hatano T et al. (2007) Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet, 16:678-90. (PubMed:17341485)
  8. Li X et al. (2011) Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS One, 6:e17153. (PubMed:21390248)
  9. Niu J et al. (2012) Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein. J Neurochem, 122:650-8. (PubMed:22639965)
  10. Parisiadou L et al. (2014) LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci, 17:367-76. (PubMed:24464040)
  11. Piccoli G et al. (2014) Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain. Mol Cell Biol, 34:2147-2161. (PubMed:24687852)
  12. Piccoli G et al. (2011) LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci, 31:2225-37. (PubMed:21307259)
  13. Stafa K et al. (2012) GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. PLoS Genet, 8:e1002526. (PubMed:22363216)
  14. Stafa K et al. (2013) Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily. Hum Mol Genet, null:null. (PubMed:24282027)
  15. Tong Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of {alpha}-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A, 107:9879-84. (PubMed:20457918)
  16. Xiong Y et al. (2012) ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. J Neurosci, 32:3877-86. (PubMed:22423108)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement

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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory