Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Aggf1. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 14, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Aggf1:
  • participates in the following biological processes:
    • cell adhesion
    • positive regulation of angiogenesis
    • positive regulation of endothelial cell proliferation
  • performs the following molecular functions:
    • eukaryotic cell surface binding
  • is located in the following cellular components:
    • cytoplasm
    • extracellular region
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Aggf1 encodes a protein or proteins that contain the following InterPro domains: Forkhead-associated (FHA) domain, G-patch domain, SMAD/FHA domain, indicating that the gene product:
  • performs the following molecular functions:
    • nucleic acid binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Aggf1 indicates that it:
  • participates in the following biological processes:
    • angiogenesis
    • cell differentiation
    • multicellular organismal development

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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