Automated description from the Alliance of Genome Resources (Release 8.1.0)
Enables nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in NAD biosynthetic process via the salvage pathway; negative regulation of DNA-templated transcription; and nicotinamide metabolic process. Acts upstream of or within several processes, including NAD biosynthetic process; negative regulation of adipose tissue development; and positive regulation of adipose tissue development. Is active in chromatin and nucleus. Is expressed in retina; retina ganglion cell layer; retina inner nuclear layer; and retina layer. Used to study Leber congenital amaurosis 9 and retinal degeneration. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 9 and spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis. Orthologous to human NMNAT1 (nicotinamide nucleotide adenylyltransferase 1).
This site uses cookies.
Some cookies are essential for site operations and others help us analyze use and utility of our web site.
Please refer to our
privacy policy
for more information.