Automated description from the Alliance of Genome Resources (Release 3.2)
Involved in Notch receptor processing; positive regulation of endopeptidase activity; and protein processing. Predicted to localize to several cellular components, including Golgi apparatus; gamma-secretase complex; and integral component of presynaptic membrane. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit).