Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tsen34. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

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Summary text based on GO annotations supported by structural data

• Tsen34 encodes a protein or proteins that contain the following InterPro domains: Endonuclease TnsA, N-terminal/resolvase Hjc/tRNA endonuclease, C-terminal, tRNA intron endonuclease, catalytic domain-like, tRNA-splicing endonuclease, tRNA-splicing endonuclease, SEN34 subunit, indicating that the gene product:
  • participates in the following biological processes:
    • tRNA splicing, via endonucleolytic cleavage and ligation
    • tRNA-type intron splice site recognition and cleavage
  • performs the following molecular functions:
    • nuclease activity
    • nucleic acid binding
    • tRNA-intron endonuclease activity
  • is located in the following cellular components:
    • tRNA-intron endonuclease complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tsen34 indicates that it:
  • participates in the following biological processes:
    • mRNA processing
    • tRNA processing
  • performs the following molecular functions:
    • endonuclease activity
    • hydrolase activity
    • nuclease activity
  • is located in the following cellular components:
    • nucleus
• Tsen34 has been associated with the Enzyme Commission numbers: 3.1.27.9, which implies that the gene product:
  • performs the following molecular functions:
    • tRNA-intron endonuclease activity
• Annotations directly to for the gene Tsen34 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res, 11:1758-65. (PubMed:11591653)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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