Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sdhc. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Sdhc
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2, 3]}

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Summary text based on GO annotations supported by structural data

• Sdhc encodes a protein or proteins that contain the following InterPro domains: Succinate dehydrogenase, cytochrome b subunit, conserved site, Succinate dehydrogenase, cytochrome b556 subunit, Succinate dehydrogenase, cytochrome b560 subunit, Succinate dehydrogenase/Fumarate reductase, transmembrane subunit, indicating that the gene product:
  • participates in the following biological processes:
    • tricarboxylic acid cycle
  • performs the following molecular functions:
    • electron carrier activity
    • oxidoreductase activity, acting on the CH-CH group of donors
    • succinate dehydrogenase activity
  • is located in the following cellular components:
    • membrane
    • succinate dehydrogenase complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sdhc indicates that it:
  • participates in the following biological processes:
    • electron transport chain
    • transport
    • tricarboxylic acid cycle
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • mitochondrial inner membrane

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References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
3. Schilling B et al. (2006) Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Biochim Biophys Acta, 1762:213-22. (PubMed:16120479)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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