Automated description from the Alliance of Genome Resources (Release 4.1.0)
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in cilium assembly; negative regulation of appetite by leptin-mediated signaling pathway; and regulation of cilium beat frequency involved in ciliary motility. Acts upstream of or within several processes, including blood vessel diameter maintenance; brain development; and regulation of actin filament organization. Located in kinociliary basal body and motile cilium. Is expressed in embryo and urogenital ridge. Used to study Bardet-Biedl syndrome 6 and obesity. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 6; McKusick-Kaufman syndrome; congenital heart disease; and obesity. Orthologous to human MKKS (MKKS centrosomal shuttling protein).